Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 137
interventional 124
Observational 12
Registry 1

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 42
Drug|Other 19
Biological 9
Drug|Radiation 8
Biological|Drug|Procedure|Radiation 6
Biological|Drug 4
Drug|Other|Radiation 4
Biological|Drug|Radiation 3
Device 3
Drug|Other|Procedure 3
Drug|Procedure 3
Radiation 3
Biological|Drug|Other|Procedure 2
Biological|Other 2
Drug|Other|Procedure|Radiation 2
Drug|Procedure|Radiation 2
Biological|Drug|Other 1
Biological|Drug|Other|Radiation 1
Biological|Drug|Procedure 1
Biological|Other|Procedure 1
Diagnostic Test|Drug|Radiation 1
Drug|Other|placebo 1
Drug|placebo 1
Procedure 1
Procedure|Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 75
United States|Puerto Rico 10
France 4
United States|Canada 4
Germany 3
China 2
United States|Australia|Canada 2
Australia|Belgium|Denmark|France|Italy|Poland|Spain|United Kingdom 1
Austria|Belgium|Czechia|Denmark|France|Germany|Ireland|Italy|Netherlands|Norway|Poland|Portugal|Spain|Sweden|Switzerland|United Kingdom 1
Canada 1
Canada|United States|Australia|Puerto Rico 1
France|United States|Australia|Canada|Italy|United Kingdom 1
Hong Kong|Japan|Taiwan 1
Ireland|United Kingdom 1
United States|Australia 1
United States|Australia|Brazil|Canada|France|Germany|Italy|Netherlands|Russian Federation|Spain|Sweden|Switzerland|United Kingdom 1
United States|Australia|Canada|Netherlands|New Zealand|Switzerland 1
United States|Australia|Canada|Netherlands|Puerto Rico 1
United States|Australia|Canada|Netherlands|Puerto Rico|Switzerland 1
United States|Australia|Canada|New Zealand 1
United States|Australia|Canada|New Zealand|Puerto Rico 1
United States|Australia|Canada|Puerto Rico 1
United States|Australia|Canada|Puerto Rico|Saudi Arabia 1
United States|Australia|Canada|Puerto Rico|Switzerland 1
United States|Austria|Czechia|Denmark|France|Norway|Spain|Sweden 1
United States|Canada|Netherlands|Puerto Rico|Switzerland 1
United States|France|Italy|Spain|United Kingdom 1
United States|Lebanon 1
United States|Netherlands|Switzerland|United Kingdom 1
United States|Spain|Switzerland|United Kingdom 1
United States|Switzerland 1

Sites per Study

Site_count Study_Count
1 54
2 5
3 2
4 2
5 3
6 2
7 1
9 5
10 3
11 5
12 2
13 2
14 2
15 3
19 1
20 1
21 2
22 1
23 1
24 1
29 1
41 2
51 1
54 1
61 1
76 1
77 1
106 2
111 2
112 1
114 1
116 1
117 1
118 2
136 1
158 1
161 1
167 1
173 1
178 1
182 1
196 1

Phase

Phase Study_Count
Phase 1 50
Phase 2 43
Phase 1/Phase 2 9
Phase 3 9
N/A 8
Early Phase 1 2
Phase 2/Phase 3 2
Phase 4 1

Number of Arms

Number_of_Arms Count_of_Studies
1 80
2 16
3 8
4 3
5 4
6 1
8 1
12 1
NA 10

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 5.00 6.00 6.00000 17.00000 8.0000 174.0 24.0000 250
1st Qu. 11.25 41.00 22.00000 33.00000 45.2500 220.5 82.0000 250
Median 17.50 74.50 30.00000 52.00000 53.0000 267.0 131.0000 250
Mean 17.50 149.25 41.36735 74.66667 134.6905 267.0 238.3333 250
3rd Qu. 23.75 193.00 55.00000 76.00000 105.5000 313.5 416.0000 250
Max. 30.00 567.00 110.00000 200.00000 1500.0000 360.0 549.0000 250

Trial Group Type

group_type Group_Count
Experimental 180
NA 10
Active Comparator 7
Other 7

Intervention Model

intervention_model Study_Count
Single Group Assignment 87
Parallel Assignment 24
NA 8
Crossover Assignment 3
Sequential Assignment 2

Primary Purpose

primary_purpose Study_Count
Treatment 116
Diagnostic 4
Supportive Care 3
Screening 1

Observational Studies

Studies by Country

Country Study_Count
United States 6
China 2
Canada 1
Germany 1
United States|Australia|Canada|New Zealand|Puerto Rico|Switzerland 1
United States|Canada 1

Sites per Study

Site_count Study_Count
1 9
9 1
66 1
187 1

Enrollment Metrics

Measure Observational
Min 76.0000
1st Qu 97.5000
Median 201.0000
Mean 420.5833
3rd Qu 425.0000
Max 1650.0000

Observation Model

observational_model Study_Count
Cohort 6
NA 3
Case-Control 2
Case-Only 1

Time Perspective

time_perspective Study_Count
Prospective 7
Retrospective 2
NA 2
Cross-Sectional 1

Registries

Studies by Country

Country Study_Count
Germany 1

Sites per Study

Site_count Study_Count
57 1

Enrollment Metrics

Measure Registries
Min 500
1st Qu 500
Median 500
Mean 500
3rd Qu 500
Max 500

Registry Model

observational_model Study_Count
Cohort 1

Time Perspective

time_perspective Study_Count
Prospective 1

Follow-up

target_duration Study_Count
5 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04334863 AflacST1901: Peds WP1066 https://ClinicalTrials.gov/show/NCT04334863 Recruiting Emory University 2023-07-31
NCT04195555 Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT04195555 Recruiting National Cancer Institute (NCI) 2025-12-31
NCT03698994 Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT03698994 Recruiting National Cancer Institute (NCI) 2025-12-31
NCT03526250 Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT03526250 Recruiting National Cancer Institute (NCI) 2025-06-30
NCT03299309 PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma https://ClinicalTrials.gov/show/NCT03299309 Recruiting Duke University 2020-12-31
NCT03273712 Dosimetry-Guided, Peptide Receptor Radiotherapy (PRRT) With 90Y-DOTA- tyr3-Octreotide (90Y-DOTATOC) https://ClinicalTrials.gov/show/NCT03273712 Recruiting University of Iowa 2020-01-31
NCT03257631 A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors https://ClinicalTrials.gov/show/NCT03257631 Active, not recruiting Celgene 2018-11-23
NCT03173950 Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers https://ClinicalTrials.gov/show/NCT03173950 Recruiting National Institutes of Health Clinical Center (CC) 2022-12-31
NCT03043391 Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children https://ClinicalTrials.gov/show/NCT03043391 Recruiting Istari Oncology, Inc. 2020-07-01
NCT03233204 Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT03233204 Recruiting National Cancer Institute (NCI) 2024-09-30
NCT02962167 Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT https://ClinicalTrials.gov/show/NCT02962167 Recruiting University of California, San Francisco 2020-11-01
NCT02875314 HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors https://ClinicalTrials.gov/show/NCT02875314 Recruiting Nationwide Children’s Hospital 2020-09-30
NCT03213704 Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT03213704 Recruiting National Cancer Institute (NCI) 2024-09-30
NCT02748135 A Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma https://ClinicalTrials.gov/show/NCT02748135 Recruiting Oncurious NV 2022-06-30
NCT02724579 Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma https://ClinicalTrials.gov/show/NCT02724579 Recruiting Children’s Oncology Group 2025-05-31
NCT03213678 PI3K/mTOR Inhibitor LY3023414 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT03213678 Recruiting National Cancer Institute (NCI) 2024-09-30
NCT03213665 Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT03213665 Recruiting National Cancer Institute (NCI) 2024-09-30
NCT02644291 Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors https://ClinicalTrials.gov/show/NCT02644291 Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2021-06-30
NCT03213652 Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT03213652 Recruiting National Cancer Institute (NCI) 2024-09-30
NCT03210714 Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) https://ClinicalTrials.gov/show/NCT03210714 Recruiting National Cancer Institute (NCI) 2024-12-31
NCT03155620 Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) https://ClinicalTrials.gov/show/NCT03155620 Recruiting National Cancer Institute (NCI) 2027-09-30
NCT03389802 Phase I Study of APX005M in Pediatric CNS Tumors https://ClinicalTrials.gov/show/NCT03389802 Recruiting Pediatric Brain Tumor Consortium 2020-09-30
NCT00840047 Methionine PET/CT Studies In Patients With Cancer https://ClinicalTrials.gov/show/NCT00840047 Recruiting St. Jude Children’s Research Hospital 2027-07-27
NCT02502708 Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors https://ClinicalTrials.gov/show/NCT02502708 Completed Lumos Pharma 2019-12-12
NCT03387020 Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors https://ClinicalTrials.gov/show/NCT03387020 Completed Pediatric Brain Tumor Consortium 2020-04-01
NCT02444546 Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors https://ClinicalTrials.gov/show/NCT02444546 Active, not recruiting Mayo Clinic 2018-07-13
NCT02441088 Theranostics: 68GaDOTATOC and 90YDOTATOC https://ClinicalTrials.gov/show/NCT02441088 Active, not recruiting University of Iowa 2020-01-31
NCT02441062 Impact of Ga-68 DOTATOC PET-CT Imaging in Management of Neuroendocrine Tumors https://ClinicalTrials.gov/show/NCT02441062 Completed University of Iowa 2020-01-20
NCT02359565 Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma https://ClinicalTrials.gov/show/NCT02359565 Recruiting National Cancer Institute (NCI) 2023-12-31
NCT02271711 Expanded Natural Killer Cell Infusion in Treating Younger Patients With Recurrent/Refractory Brain Tumors https://ClinicalTrials.gov/show/NCT02271711 Active, not recruiting M.D. Anderson Cancer Center 2020-03-30
NCT02162732 Molecular-Guided Therapy for Childhood Cancer https://ClinicalTrials.gov/show/NCT02162732 Active, not recruiting Spectrum Health Hospitals 2020-06-30
NCT02095132 Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors https://ClinicalTrials.gov/show/NCT02095132 Active, not recruiting National Cancer Institute (NCI) 2021-04-30
NCT02066220 International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma https://ClinicalTrials.gov/show/NCT02066220 Recruiting Universitätsklinikum Hamburg-Eppendorf 2024-04-30
NCT02040376 Placebo Controlled Double Blind Crossover Trial of Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma https://ClinicalTrials.gov/show/NCT02040376 Completed The Hospital for Sick Children 2017-12-31
NCT02017964 Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma https://ClinicalTrials.gov/show/NCT02017964 Active, not recruiting Children’s Oncology Group 2018-03-31
NCT02025881 Study of Sequential High-dose Chemotherapy in Children With High Risk Medulloblastoma https://ClinicalTrials.gov/show/NCT02025881 Recruiting Gustave Roussy, Cancer Campus, Grand Paris 2018-09-30
NCT01977677 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma https://ClinicalTrials.gov/show/NCT01977677 Completed Stanford University 2017-11-30
NCT01975116 p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors https://ClinicalTrials.gov/show/NCT01975116 Completed Pediatric Brain Tumor Consortium 2015-04-30
NCT01878617 A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma https://ClinicalTrials.gov/show/NCT01878617 Recruiting St. Jude Children’s Research Hospital 2023-06-30
NCT01869725 Ga-DOTATOC Versus Octreoscan + CT https://ClinicalTrials.gov/show/NCT01869725 Completed University of Iowa 2018-12-26
NCT01857453 Interest of a Dose Decrease for Radiotherapy Associated With Chemotherapy for Treatment of Standard Risk Adult Medulloblastomas https://ClinicalTrials.gov/show/NCT01857453 Recruiting Central Hospital, Nancy, France 2018-12-31
NCT01802567 Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer https://ClinicalTrials.gov/show/NCT01802567 Active, not recruiting Spectrum Health Hospitals 2019-12-31
NCT01708174 A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB) https://ClinicalTrials.gov/show/NCT01708174 Completed Novartis 2016-10-05
NCT01619865 Safety of 68Ga-DOTA-tyr3-Octreotide PET in Diagnosis of Solid Tumors https://ClinicalTrials.gov/show/NCT01619865 Active, not recruiting University of Iowa 2017-08-27
NCT01542736 Concurrent Carboplatin and Reduced Dose Craniospinal Radiation for Medulloblastoma and Primitive Neuroectodermal Tumor (PNET) https://ClinicalTrials.gov/show/NCT01542736 Completed University of Colorado, Denver 2015-11-30
NCT01505569 Auto Transplant for High Risk or Relapsed Solid or CNS Tumors https://ClinicalTrials.gov/show/NCT01505569 Recruiting Masonic Cancer Center, University of Minnesota 2021-03-31
NCT01356290 Metronomic and Targeted Anti-angiogenesis Therapy for Children With Recurrent/Progressive Medulloblastoma https://ClinicalTrials.gov/show/NCT01356290 Recruiting Medical University of Vienna 2021-04-30
NCT01351870 Hyperfractionated Versus Conventionally Fractionated Radiotherapy in Standard Risk Medulloblastoma https://ClinicalTrials.gov/show/NCT01351870 Active, not recruiting Institut Curie 2008-12-31
NCT01326104 Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor https://ClinicalTrials.gov/show/NCT01326104 Active, not recruiting University of Florida 2020-09-30
NCT04315064 Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults With Recurrent Medulloblastoma https://ClinicalTrials.gov/show/NCT04315064 Recruiting The University of Texas Health Science Center, Houston 2022-12-30
NCT04185038 Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors https://ClinicalTrials.gov/show/NCT04185038 Recruiting Seattle Children’s Hospital 2026-05-31
NCT04049669 Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG https://ClinicalTrials.gov/show/NCT04049669 Recruiting Augusta University 2024-10-02
NCT04023669 Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors https://ClinicalTrials.gov/show/NCT04023669 Recruiting St. Jude Children’s Research Hospital 2025-06-30
NCT03990597 StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord https://ClinicalTrials.gov/show/NCT03990597 Recruiting M.D. Anderson Cancer Center 2020-05-31
NCT03904862 Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery https://ClinicalTrials.gov/show/NCT03904862 Recruiting Pediatric Brain Tumor Consortium 2022-05-01
NCT03893487 Fimepinostat in Treating Brain Tumors in Children and Young Adults https://ClinicalTrials.gov/show/NCT03893487 Recruiting University of California, San Francisco 2022-06-01
NCT03734913 A Phase 1 Study of ZSP1602 in Participants With Advanced Solid Tumors https://ClinicalTrials.gov/show/NCT03734913 Recruiting Guangdong Zhongsheng Pharmaceutical Co., Ltd. 2020-11-01
NCT03709680 Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors https://ClinicalTrials.gov/show/NCT03709680 Recruiting Pfizer 2021-02-16
NCT03675230 Study of Tomotherapy HD in Medulloblastoma https://ClinicalTrials.gov/show/NCT03675230 Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine 2019-05-30
NCT03638167 EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors https://ClinicalTrials.gov/show/NCT03638167 Recruiting Seattle Children’s Hospital 2022-03-31
NCT03615404 Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients and Young Adults With WHO Grade IV Glioma, Recurrent Malignant Glioma, or Recurrent Medulloblastoma https://ClinicalTrials.gov/show/NCT03615404 Active, not recruiting Duke University 2019-11-19
NCT03598244 Volitinib in Treating Participants With Recurrent or Refractory Primary CNS Tumors https://ClinicalTrials.gov/show/NCT03598244 Recruiting National Cancer Institute (NCI) 2020-12-31
NCT03500991 HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors https://ClinicalTrials.gov/show/NCT03500991 Recruiting Seattle Children’s Hospital 2021-07-26
NCT03434262 SJDAWN: St. Jude Children’s Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors https://ClinicalTrials.gov/show/NCT03434262 Recruiting St. Jude Children’s Research Hospital 2025-02-28
NCT01239316 Vismodegib in Treating Younger Patients With Recurrent or Refractory Medulloblastoma https://ClinicalTrials.gov/show/NCT01239316 Completed National Cancer Institute (NCI) 2014-06-30
NCT01217437 Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors https://ClinicalTrials.gov/show/NCT01217437 Active, not recruiting National Cancer Institute (NCI) 2017-12-31
NCT01208831 An East Asian Study of LDE225 https://ClinicalTrials.gov/show/NCT01208831 Completed Novartis 2013-10-31
NCT01171469 Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor https://ClinicalTrials.gov/show/NCT01171469 Completed Masonic Cancer Center, University of Minnesota 2012-05-31
NCT01125800 A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB https://ClinicalTrials.gov/show/NCT01125800 Completed Novartis 2014-10-31
NCT01119599 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma https://ClinicalTrials.gov/show/NCT01119599 Completed National Cancer Institute (NCI) 2013-06-30
NCT01106508 A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors https://ClinicalTrials.gov/show/NCT01106508 Completed Novartis 2015-06-30
NCT01076530 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors https://ClinicalTrials.gov/show/NCT01076530 Completed National Cancer Institute (NCI) 2012-10-31
NCT01063114 Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma https://ClinicalTrials.gov/show/NCT01063114 Active, not recruiting Massachusetts General Hospital 2021-11-30
NCT00994500 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma https://ClinicalTrials.gov/show/NCT00994500 Completed National Cancer Institute (NCI) 2011-07-31
NCT00994071 A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors https://ClinicalTrials.gov/show/NCT00994071 Completed National Institutes of Health Clinical Center (CC) NA
NCT00946335 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors https://ClinicalTrials.gov/show/NCT00946335 Completed National Cancer Institute (NCI) 2011-10-31
NCT00939484 Vismodegib in Treating Patients With Recurrent or Refractory Medulloblastoma https://ClinicalTrials.gov/show/NCT00939484 Completed National Cancer Institute (NCI) 2013-05-31
NCT00880308 Dose Finding and Safety of Oral LDE225 in Patients With Advanced Solid Tumors https://ClinicalTrials.gov/show/NCT00880308 Completed Novartis 2013-07-31
NCT00867568 TPI 287 in Patients With Refractory or Recurrent Neuroblastoma or Medulloblastoma https://ClinicalTrials.gov/show/NCT00867568 Completed Spectrum Health Hospitals 2011-09-30
NCT00867178 Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System https://ClinicalTrials.gov/show/NCT00867178 Active, not recruiting National Cancer Institute (NCI) 2018-12-30
NCT00822458 GDC-0449 in Treating Young Patients With Medulloblastoma That is Recurrent or Did Not Respond to Previous Treatment https://ClinicalTrials.gov/show/NCT00822458 Completed National Cancer Institute (NCI) 2013-09-30
NCT01614132 Multicenter Pilot-study for the Therapy of Medulloblastoma of Adults https://ClinicalTrials.gov/show/NCT01614132 Completed University of Regensburg 2018-10-31
NCT01331135 Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors https://ClinicalTrials.gov/show/NCT01331135 Completed Emory University 2017-08-09
NCT03911388 HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors https://ClinicalTrials.gov/show/NCT03911388 Recruiting University of Alabama at Birmingham 2023-09-01
NCT00749723 Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children https://ClinicalTrials.gov/show/NCT00749723 Completed University Hospital, Bonn 2015-01-31
NCT00716976 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy https://ClinicalTrials.gov/show/NCT00716976 Completed Children’s Oncology Group 2015-04-30
NCT00601003 Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma https://ClinicalTrials.gov/show/NCT00601003 Active, not recruiting Spectrum Health Hospitals 2020-05-01
NCT00638898 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor https://ClinicalTrials.gov/show/NCT00638898 Active, not recruiting City of Hope Medical Center 2020-09-01
NCT00520936 A Study of Pemetrexed in Children With Recurrent Cancer https://ClinicalTrials.gov/show/NCT00520936 Completed Eli Lilly and Company 2010-02-28
NCT00019578 Stereotactic Radiosurgery in Treating Patients With Brain Tumors https://ClinicalTrials.gov/show/NCT00019578 Completed National Institutes of Health Clinical Center (CC) NA
NCT00407433 Clinical Studies of Gemcitabine-Oxaliplatin https://ClinicalTrials.gov/show/NCT00407433 Completed Gustave Roussy, Cancer Campus, Grand Paris NA
NCT00404495 Combination of Irinotecan and Temozolomide in Children With Brain Tumors. https://ClinicalTrials.gov/show/NCT00404495 Completed Pfizer 2011-01-31
NCT00392327 Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET https://ClinicalTrials.gov/show/NCT00392327 Active, not recruiting Children’s Oncology Group 2019-06-30
NCT00381797 Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma https://ClinicalTrials.gov/show/NCT00381797 Completed National Cancer Institute (NCI) 2015-10-31
NCT00326664 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors https://ClinicalTrials.gov/show/NCT00326664 Completed National Cancer Institute (NCI) 2015-07-31
NCT00363272 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma https://ClinicalTrials.gov/show/NCT00363272 Completed National Cancer Institute (NCI) 2008-10-31
NCT00336024 Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma https://ClinicalTrials.gov/show/NCT00336024 Active, not recruiting Children’s Oncology Group 2016-12-31
NCT00303810 Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma https://ClinicalTrials.gov/show/NCT00303810 Completed Universitätsklinikum Hamburg-Eppendorf 2013-12-31
NCT00217412 Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia https://ClinicalTrials.gov/show/NCT00217412 Completed National Cancer Institute (NCI) 2009-09-30
NCT00105560 Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma https://ClinicalTrials.gov/show/NCT00105560 Active, not recruiting Massachusetts General Hospital 2012-12-31
NCT00101270 Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas https://ClinicalTrials.gov/show/NCT00101270 Completed National Cancer Institute (NCI) 2007-09-30
NCT00100880 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors https://ClinicalTrials.gov/show/NCT00100880 Completed National Cancer Institute (NCI) 2010-11-30
NCT00095940 Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors https://ClinicalTrials.gov/show/NCT00095940 Completed National Cancer Institute (NCI) 2010-07-31
NCT00085735 Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma https://ClinicalTrials.gov/show/NCT00085735 Active, not recruiting Children’s Oncology Group 2016-03-31
NCT00085202 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor https://ClinicalTrials.gov/show/NCT00085202 Active, not recruiting St. Jude Children’s Research Hospital 2016-12-31
NCT00002875 Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma https://ClinicalTrials.gov/show/NCT00002875 Completed Children’s Oncology Group 2006-02-28
NCT00003573 Etoposide Plus Radiation Therapy Followed by Combination Chemotherapy in Treating Children With Newly Diagnosed Advanced Medulloblastoma https://ClinicalTrials.gov/show/NCT00003573 Completed Children’s Oncology Group 2007-10-31
NCT00077454 Erlotinib and Temozolomide in Treating Young Patients With Recurrent or Refractory Solid Tumors https://ClinicalTrials.gov/show/NCT00077454 Completed National Cancer Institute (NCI) 2007-09-30
NCT00070525 Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma https://ClinicalTrials.gov/show/NCT00070525 Completed National Cancer Institute (NCI) 2006-09-30
NCT00063973 Cilengitide in Treating Children With Refractory Primary Brain Tumors https://ClinicalTrials.gov/show/NCT00063973 Completed National Cancer Institute (NCI) 2008-03-31
NCT00003211 Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor https://ClinicalTrials.gov/show/NCT00003211 Completed St. Jude Children’s Research Hospital 2007-06-30
NCT00058370 Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma https://ClinicalTrials.gov/show/NCT00058370 Completed Memorial Sloan Kettering Cancer Center 2019-06-30
NCT00053963 FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia https://ClinicalTrials.gov/show/NCT00053963 Completed National Cancer Institute (NCI) 2006-02-28
NCT00004078 Irinotecan in Treating Children With Refractory Solid Tumors https://ClinicalTrials.gov/show/NCT00004078 Completed Children’s Oncology Group 2007-10-31
NCT00052780 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors https://ClinicalTrials.gov/show/NCT00052780 Completed National Cancer Institute (NCI) 2007-11-30
NCT00047177 Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor https://ClinicalTrials.gov/show/NCT00047177 Completed Pediatric Brain Tumor Consortium 2004-08-31
NCT00025077 Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors https://ClinicalTrials.gov/show/NCT00025077 Completed National Cancer Institute (NCI) NA
NCT00012181 Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas https://ClinicalTrials.gov/show/NCT00012181 Completed National Cancer Institute (NCI) 2005-01-31
NCT00006461 Combination Chemotherapy Followed by Second-Look Surgery and Radiation Therapy in Treating Children With Nonmetastatic Medulloblastoma or Primitive Neuroectodermal Tumor https://ClinicalTrials.gov/show/NCT00006461 Completed Children’s Oncology Group 2007-09-30
NCT00005811 Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment https://ClinicalTrials.gov/show/NCT00005811 Completed National Cancer Institute (NCI) 2006-04-30
NCT00003309 Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer https://ClinicalTrials.gov/show/NCT00003309 Completed Eastern Cooperative Oncology Group 2004-03-31
NCT00002594 Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors https://ClinicalTrials.gov/show/NCT00002594 Completed Children’s Oncology Group 2003-09-30
NCT00001502 A Pediatric Phase I Trial of RMP-7 and Carboplatin in Brain Tumors https://ClinicalTrials.gov/show/NCT00001502 Completed National Institutes of Health Clinical Center (CC) NA
NCT00006258 Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma https://ClinicalTrials.gov/show/NCT00006258 Completed National Cancer Institute (NCI) NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03361033 Components of Social Functioning in Survivors of Pediatric Brain Tumors https://ClinicalTrials.gov/show/NCT03361033 Active, not recruiting St. Jude Children’s Research Hospital 2021-02-28
NCT03288168 Children’s and Adolescents’ Medulloblastoma Molecular Subgroups in China https://ClinicalTrials.gov/show/NCT03288168 Active, not recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine 2020-12-31
NCT03251989 Rare CNS Tumors Outcomes &Risk https://ClinicalTrials.gov/show/NCT03251989 Recruiting National Institutes of Health Clinical Center (CC) 2022-02-01
NCT02747576 Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma https://ClinicalTrials.gov/show/NCT02747576 Completed St. Jude Children’s Research Hospital 2018-06-25
NCT02238899 Multicenter Register for Children and Young Adults With Intracranial Localized Medulloblastoma, CNS-PNET or Ependymoma https://ClinicalTrials.gov/show/NCT02238899 Completed Universitätsklinikum Hamburg-Eppendorf 2014-12-31
NCT04081701 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. https://ClinicalTrials.gov/show/NCT04081701 Recruiting Weill Medical College of Cornell University 2021-08-30
NCT04065204 Metabolomic Analysis of Body Fluid of Medulloblastoma in Children https://ClinicalTrials.gov/show/NCT04065204 Enrolling by invitation Xinhua Hospital, Shanghai Jiao Tong University School of Medicine 2022-06-01
NCT03583528 DOTATOC PET/CT for Imaging NET Patients https://ClinicalTrials.gov/show/NCT03583528 Recruiting British Columbia Cancer Agency 2023-12-31
NCT00919750 Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors https://ClinicalTrials.gov/show/NCT00919750 Completed Children’s Oncology Group 2018-06-30
NCT00898755 Collecting and Storing Tissue From Young Patients With Cancer https://ClinicalTrials.gov/show/NCT00898755 Completed Children’s Oncology Group 2008-07-17
NCT00897286 Study of Stored Tumor Samples in Young Patients With Brain Tumors https://ClinicalTrials.gov/show/NCT00897286 Recruiting St. Jude Children’s Research Hospital 2026-02-28
NCT01445288 Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors https://ClinicalTrials.gov/show/NCT01445288 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02417324 International HIT-MED Registry (I-HIT-MED) https://ClinicalTrials.gov/show/NCT02417324 Recruiting Universitätsklinikum Hamburg-Eppendorf 2019-12-31